From Lab Coats to Lat Spreads: Volume I

Above: Yohimbine, Yohimbe tree.

Science can help with your athletic performance, muscular size, and strength levels.  In these issues we will examine specific compounds/protocols and the studies behind them to help make them accessible to the average meathead.

In this article we will examine Yohimbine HCL, a fat burning compound.  How to dose, side effects, efficacy, and expected results will all be looked at.

Yohimbine is the primary alkaloid in the bark of the Yohimbe Tree.  The bark of the yohimbe tree has been used for years as an aphrodisiac, and is reportedly hallucinogenic when smoked.  The hallucinations are reportedly extremely bad in nature however, so it is not recommended to smoke the bark.  The tree is native to Africa, and its bark is used in many different rituals due to the qualities stated above.  Yohimbine turns out to be a pretty potent fatburner as well, which is mainly the quality we are interested in for performance purposes, although its status as a natural aphrodisiac can also be desired.

Yohimbine is an efficient fat burner for a couple of reasons.  This study showed a significant decrease in fat mass for the soccer players using Yohimbine versus the ones that didn’t.  The theorized mechanisms for Yohimbine being an efficient fatburner are as follows:

1.  Yohimbine causes a release of norepinephrine, which is a hormone and neurotransmitter that can cause fat to be burned(lipolysis).  This leads to the second mechanism:

2. Some fatty areas have a receptor known as the A2 andrenergic receptor.  Some areas of the body hold fat that is “stubborn,” usually estrogenic in nature, and these areas also have a high A2 receptor density.  The problem is that noradrenaline has a high affinity for these receptors, and once bound, it cannot exert its effects on the fatty tissue.  Yohimbine turns out to have a very high affinity for these A2 receptors as well.  So what you end up getting is a release of a fat burning compound and a blocking of the receptors that can inhibit this compound!  A double whammy.

The side effects of this drug are well known, but seem to be very individual.  Some people can dose it extremely high and experience little to no side effects, but some people experience severe side effects at relatively low dosages.  The main reported side effect is anxiety, so this is not recommended if you already have anxiety symptoms.  The other side effects include rapid heart rate, extreme stimulation, high blood pressure, and insomnia.  These were much more rare, and can be easily avoided by moderating the dose or cutting it out completely if that does not do the trick.  If a psychological disorder is present, a psychoactive drug is not recommended, ever.

Since this compound is so potent, the dosage becomes very important.  The effective dose for fatloss seems to be .2mg/kg, or approximately .1mg/lb of bodyweight.  So if you are 200lbs, you will take 20mg a day.  The timing of these doses is important too, since according to the literature, yohimbine is metabolized very fast by the body.  Its halflife in the bloodstream turns out to be around 35 minutes, so almost all of it will be eliminated by the 2hr mark.  Thus the recommended dosing will be your total daily dose divided into three doses spread 2.5-3 hours apart.  As always, start VERY slowly with this compound, as it has some pretty harsh side effects if you have a low tolerance for it, or dose it too high.

So there you have it, yohimbine is a very effective compound that is completely legal at this point in the U.S.  Stay tuned for more articles in the Labcoats to Latspread series.


WARNING:  Use advice in this article at your own risk. is not responsible for any actions or harm that may come from the advise within this article.  Do NOT use yohimbine unless you are prepared to accept the repercussions and possible side effects caused by the use of this compound.


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4 Responses to From Lab Coats to Lat Spreads: Volume I

  1. JarradHall says:

    I wish this wasn’t illegal down under 🙁

  2. I really loved your blog, but it appears that you have put a lot more work into it. I will keep your blog in my twitter so I can come back and see it again when it has some new information. Good subject!

    • Hey- Thanks man! There are a couple new articles coming out, explaining each of the macronutrients and their importance in your diet.

      I’m curious, in what capacity are you connected with Fisher Scientific? I know a couple people that have been hired by them.


  3. Marina says:

    You have really interesting blog, keep up posting such informative posts!

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